THE BRAIN: AN ELECTRICAL AND CHEMICAL MACHINE

THE BRAIN: AN ELECTRICAL AND CHEMICAL MACHINE

The brain functions as an incredibly sophisticated electrical and chemical machine, using a seamless two-step process to transmit and process information via its fundamental unit, the neuron (nerve cell).¹

The communication within the brain relies on the following cycle:

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⚡ 1. The Electrical Signal (Action Potential)²

Information travels rapidly within a single neuron as an electrical signal called an action potential (or nerve impulse).³

• Basis: The neuron maintains an electrical charge difference, or resting membrane potential, across its cell membrane, established by an unequal distribution of positively and negatively charged ions (primarily Sodium (⁴$Na^+$), Potassium (⁵$K^+$), and Chloride (⁶$Cl^-$)) inside versus outside the cell.⁷

• Firing: When a neuron receives enough stimulation from its neighbors to reach a specific voltage threshold, voltage-gated ion channels rapidly open.⁸

  • This causes a sudden, massive influx of positive ions (⁹$Na^+$) into the cell, which momentarily reverses the electrical charge from negative to positive—this is the action potential.¹⁰

• Propagation: This electrical spike then travels quickly and in an all-or-nothing fashion down the length of the neuron's transmitting fiber, the axon, until it reaches the end terminal.¹¹

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🧪 2. The Chemical Signal (Neurotransmitters)¹²

Once the electrical signal reaches the end of the axon, it must cross a tiny gap, the synapse, to communicate with the next neuron.¹³ This is where the signal converts from electrical to chemical.¹⁴

• Conversion and Release: When the action potential arrives at the axon terminal, it triggers the release of specialized chemical messengers called neurotransmitters into the synaptic cleft (the gap).¹⁵

• Crossing the Synapse: The neurotransmitters quickly diffuse across this gap and bind to receptors on the receiving neuron's dendrites.¹⁶ This binding is specific, like a key fitting a specific lock.¹⁷

• Effect: The action of the neurotransmitter on the receptor determines the next step for the receiving neuron:¹⁸

  • Excitatory Neurotransmitters (e.g., Glutamate) push the receiving neuron's voltage toward its firing threshold, making it more likely to generate its own action potential.¹⁹

  • Inhibitory Neurotransmitters (e.g., GABA) push the voltage away from the firing threshold, making it less likely to fire.²⁰

By constantly integrating thousands of these excitatory and inhibitory chemical inputs, the receiving neuron determines whether to generate its own electrical signal, thereby perpetuating the communication throughout the brain's vast neural circuits.²¹

Key Chemical Messengers

Neurotransmitter	Primary Role(s)
Glutamate	Major Excitatory neurotransmitter; learning and memory.
GABA (Gamma-Aminobutyric Acid)	Major Inhibitory neurotransmitter; calming, anxiety regulation.
Dopamine	Reward, motivation, motor control.
Serotonin	Mood, sleep, appetite.
Acetylcholine	Muscle contraction (PNS), attention, memory (CNS).

Diagram of Brain

Let's start looking at the building blocks of the brain. As previously stated, the brain consists of about 100 billion cells. Most of these cells are called neurons. A neuron is basically an on/off switch just like the one you use to control the lights in your home. 

It is either in a resting state (off) or it is shooting an electrical impulse down a wire (on). It has a cell body, a long little wire (the "wire" is called an axon), and at the very end it has a little part that shoots out a chemical. This chemical goes across a gap (synapse) where it triggers another neuron to send a message. 

There are a lot of these neurons sending messages down a wire (axon). By the way, each of these billions of axons is generating a small amount of electrical charge; this total power has been estimated to equal a 60 watt bulb.

 Doctors have learned that measuring this electrical activity can tell how the brain is working. A device that measures electrical activity in the brain is called an EEG (electroencephalograph).

Each of the billions of neurons "spit out" chemicals that trigger other neurons. Different neurons use different types of chemicals. These chemicals are called "transmitters" and are given names like epinephrine, norepinephrine, or dopamine. Diagram of Brain

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